Green Lab

Abby Green, MD

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Cancer develops through accumulation of DNA mutations and structural aberrations collectively known as genome instability.

Genome damage in adult-onset malignancies can be traced to exogenous carcinogens or simply the process of aging. However, pediatric cancers do not arise as a result of aging or exogenous genotoxic agents. We are interested in the etiology of genome instability in pediatric cancers and the resulting genome-protective responses, also called DNA damage responses, that are activated. Our long-term goal is to identify predictors of mutagenesis and therapeutic vulnerabilities within DNA damage response pathways in order to develop new treatment options for children with cancer.

Principal investigator

Abby M. Green, MD

Abby M. Green, MD

Assistant Professor of Pediatrics, Infectious Diseases

  @AbbyGreenLab

Research profile

Publications

  • MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks
    MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaksMathias, B., O'Leary, D., Saucier, N., Ahmad, F., White, L. S., Russell, LM. M., Shinawi, M., Smith, M. J., Abraham, R. S., Cooper, M. A., Kitcharoensakkul, M., Green, A. M. & Bednarski, J. J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1113-1124.e7Research output: Contribution to journal › Article › peer-review
  • Infectious complications of vascular anomalies treated with sirolimus: A systematic review
    Infectious complications of vascular anomalies treated with sirolimus: A systematic reviewKalbfell, R., Cohen-Cutler, S., Grisham, E., Bereitschaft, C., Borst, A. J., Green, A. M., Willis, D. N., Yaeger, L., Blatt, J. & Sisk, B. A., Jan 2024, In: Pediatric Blood and Cancer. 71, 1, e30758.Research output: Contribution to journal › Review article › peer-review
  • Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells
    Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cellsJohnston, R., Mathias, B., Crowley, S. J., Schmidt, H. A., White, L. S., Mosammaparast, N., Green, A. M. & Bednarski, J. J., Jan 9 2023, In: EMBO Reports. 24, 1, e55429.Research output: Contribution to journal › Article › peer-review
  • Antigen glycosylation regulates efficacy of CAR T cells targeting CD19
    Antigen glycosylation regulates efficacy of CAR T cells targeting CD19Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.Research output: Contribution to journal › Article › peer-review
  • Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
    Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancerPetljak, M., Green, A. M., Maciejowski, J. & Weitzman, M. D., Nov 2022, In: Nature Genetics. 54, 11, p. 1599-1608 10 p.Research output: Contribution to journal › Article › peer-review
  • Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
    Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancersDeWeerd, R. A., Németh, E., Póti, Á., Petryk, N., Chen, C. L., Hyrien, O., Szüts, D. & Green, A. M., Mar 22 2022, In: Cell Reports. 38, 12, 110555.Research output: Contribution to journal › Article › peer-review
  • Antiviral Therapeutics in Pediatric Transplant Recipients
    Antiviral Therapeutics in Pediatric Transplant RecipientsOtto, W. R. & Green, A., Mar 2022, In: Infectious disease clinics of North America. 36, 1, p. 125-146 22 p.Research output: Contribution to journal › Review article › peer-review
  • Qualitative and Quantitative Analysis of DNA Cytidine Deaminase Activity
    Qualitative and Quantitative Analysis of DNA Cytidine Deaminase ActivityDeWeerd, R. & Green, A. M., 2022, Methods in Molecular Biology. Humana Press Inc., p. 161-169 9 p. (Methods in Molecular Biology; vol. 2444).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
  • Controllable genome editing with split-engineered base editors
    Controllable genome editing with split-engineered base editorsBerríos, K. N., Evitt, N. H., DeWeerd, R. A., Ren, D., Luo, M., Barka, A., Wang, T., Bartman, C. R., Lan, Y., Green, A. M., Shi, J. & Kohli, R. M., Dec 2021, In: Nature Chemical Biology. 17, 12, p. 1262-1270 9 p.Research output: Contribution to journal › Article › peer-review
  • Interaction with the CCT chaperonin complex limits APOBEC3A cytidine deaminase cytotoxicity
    Interaction with the CCT chaperonin complex limits APOBEC3A cytidine deaminase cytotoxicityGreen, A. M., DeWeerd, R. A., O’Leary, D. R., Hansen, A. R., Hayer, K. E., Kulej, K., Dineen, A. S., Szeto, J. H., Garcia, B. A. & Weitzman, M. D., Sep 6 2021, In: EMBO Reports. 22, 9, e52145.Research output: Contribution to journal › Article › peer-review
Complete research profile