Green Lab

Abby Green, MD

Click to see this content

Cancer develops through accumulation of DNA mutations and structural aberrations collectively known as genome instability.

Genome damage in adult-onset malignancies can be traced to exogenous carcinogens or simply the process of aging. However, pediatric cancers do not arise as a result of aging or exogenous genotoxic agents. We are interested in the etiology of genome instability in pediatric cancers and the resulting genome-protective responses, also called DNA damage responses, that are activated. Our long-term goal is to identify predictors of mutagenesis and therapeutic vulnerabilities within DNA damage response pathways in order to develop new treatment options for children with cancer.

Principal investigator

Abby M. Green, MD

Abby M. Green, MD

Assistant Professor of Pediatrics, Infectious Diseases

  @AbbyGreenLab

Research profile

Publications

  • Approach for defining human adenovirus infection and disease for central review adjudication in clinical studies
    Approach for defining human adenovirus infection and disease for central review adjudication in clinical studiesFisher, B. T., Blumenstock, J., Boge, C. L. K., Shuster, S., Seif, A. E., Green, M., Michaels, M. G., Alexander, J. L., Ardura, M. I., Miller, T. P., Hijano, D. R., Muller, W. J., Schuster, J. E., Green, A. M., Dulek, D. E., Kajon, A. E. & Danziger-Isakov, L., May 2024, In: Pediatric transplantation. 28, 3, e14750.Research output: Contribution to journal › Article › peer-review
  • MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks
    MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaksMathias, B., O'Leary, D., Saucier, N., Ahmad, F., White, L. S., Russell, L. M., Shinawi, M., Smith, M. J., Abraham, R. S., Cooper, M. A., Kitcharoensakkul, M., Green, A. M. & Bednarski, J. J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1113-1124.e7Research output: Contribution to journal › Article › peer-review
  • Virus-Specific T Cells for the Treatment of Systemic Infections Following Allogeneic Hematopoietic Cell and Solid Organ Transplantation
    Virus-Specific T Cells for the Treatment of Systemic Infections Following Allogeneic Hematopoietic Cell and Solid Organ TransplantationGreen, A., Rubinstein, J. D., Grimley, M. & Pfeiffer, T., Feb 1 2024, In: Journal of the Pediatric Infectious Diseases Society. 13, p. S49-S57Research output: Contribution to journal › Review article › peer-review
  • Infectious complications of vascular anomalies treated with sirolimus: A systematic review
    Infectious complications of vascular anomalies treated with sirolimus: A systematic reviewKalbfell, R., Cohen-Cutler, S., Grisham, E., Bereitschaft, C., Borst, A. J., Green, A. M., Willis, D. N., Yaeger, L., Blatt, J. & Sisk, B. A., Jan 2024, In: Pediatric Blood and Cancer. 71, 1, e30758.Research output: Contribution to journal › Review article › peer-review
  • Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantation
    Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantationPfeiffer, T., Lockowitz, C. R., Shenoy, S., Mavers, M., Hayashi, R., Bednarski, J. & Green, A., 2024, (Accepted/In press) In: Bone Marrow Transplantation.Research output: Contribution to journal › Letter › peer-review
  • The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress
    The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stressFingerman, D. F., O’Leary, D. R., Hansen, A. R., Tran, T., Harris, B. R., DeWeerd, R. A., Hayer, K. E., Fan, J., Chen, E., Tennakoon, M., Meroni, A., Szeto, J. H., Devenport, J., LaVigne, D., Weitzman, M. D., Shalem, O., Bednarski, J., Vindigni, A., Zhao, X. & Green, A., 2024, (Accepted/In press) In: EMBO Journal.Research output: Contribution to journal › Article › peer-review
  • Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells
    Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cellsJohnston, R., Mathias, B., Crowley, S. J., Schmidt, H. A., White, L. S., Mosammaparast, N., Green, A. M. & Bednarski, J. J., Jan 9 2023, In: EMBO Reports. 24, 1, e55429.Research output: Contribution to journal › Article › peer-review
  • Antigen glycosylation regulates efficacy of CAR T cells targeting CD19
    Antigen glycosylation regulates efficacy of CAR T cells targeting CD19Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.Research output: Contribution to journal › Article › peer-review
  • Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
    Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancerPetljak, M., Green, A. M., Maciejowski, J. & Weitzman, M. D., Nov 2022, In: Nature Genetics. 54, 11, p. 1599-1608 10 p.Research output: Contribution to journal › Article › peer-review
  • Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
    Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancersDeWeerd, R. A., Németh, E., Póti, Á., Petryk, N., Chen, C. L., Hyrien, O., Szüts, D. & Green, A. M., Mar 22 2022, In: Cell Reports. 38, 12, 110555.Research output: Contribution to journal › Article › peer-review
Complete research profile