Green Lab

Abby Green, MD

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Cancer develops through accumulation of DNA mutations and structural aberrations collectively known as genome instability.

Genome damage in adult-onset malignancies can be traced to exogenous carcinogens or simply the process of aging. However, pediatric cancers do not arise as a result of aging or exogenous genotoxic agents. We are interested in the etiology of genome instability in pediatric cancers and the resulting genome-protective responses, also called DNA damage responses, that are activated. Our long-term goal is to identify predictors of mutagenesis and therapeutic vulnerabilities within DNA damage response pathways in order to develop new treatment options for children with cancer.

Principal investigator

Our team

Publications

  • BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability
    BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instabilitySitu, K., Duan, H., Godin, S. K., Yang, J., McCloskey, G. Q., Naeem, B., Gillis, M. K., Zeb, M. H., Salhotra, S., Rawal, P., Patel, N., Mouliere, S. K., Chen, J., Békési, A., Pálinkás, H. L., Venkatesan, S., Green, A. M., Birkbak, N. J., Vértessy, B. G. & Swanton, C. & 1 others, Pathania, S., Dec 2025, In: Nature communications. 16, 1, 9544.Research output: Contribution to journal › Article › peer-review
  • Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe
    Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastropheOrtega, P., Bournique, E., Li, J., Sanchez, A., Santiago, G., Harris, B. R., Striepen, J., Maciejowski, J., Green, A. M. & Buisson, R., Apr 18 2025, In: Science Advances. 11, 16, eadu0437.Research output: Contribution to journal › Article › peer-review
  • APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition
    APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transitionDevenport, J. M., Tran, T., Harris, B. R., Fingerman, D., DeWeerd, R. A., Elkhidir, L. H., LaVigne, D., Fuh, K., Sun, L., Bednarski, J. J., Drapkin, R., Mullen, M. M. & Green, A. M., Mar 10 2025, In: JCI Insight. 10, 5, e186409.Research output: Contribution to journal › Article › peer-review
  • Infections in Pediatric Lung Transplantation
    Infections in Pediatric Lung TransplantationGreen, A. M. & Danziger-Isakov, L., Jan 1 2025, Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 9th Edition: 2-Volume Set. Elsevier, Vol. 1-2. p. 706-720.e7 Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
  • Defining the genome-wide mutagenic impact of APOBEC3 enzymes
    Defining the genome-wide mutagenic impact of APOBEC3 enzymesNémeth, E., DeWeerd, R. A., Green, A. M. & Szüts, D., Jan 2025, Apobec Enzymes. Academic Press Inc., p. 101-114 14 p. (Methods in Enzymology; vol. 713).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
  • The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress
    The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stressFingerman, D. F., O’Leary, D. R., Hansen, A. R., Tran, T., Harris, B. R., DeWeerd, R. A., Hayer, K. E., Fan, J., Chen, E., Tennakoon, M., Meroni, A., Szeto, J. H., Devenport, J., LaVigne, D., Weitzman, M. D., Shalem, O., Bednarski, J., Vindigni, A., Zhao, X. & Green, A. M., Aug 1 2024, In: EMBO Journal. 43, 15, p. 3240-3255 16 p.Research output: Contribution to journal › Article › peer-review
  • Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantation
    Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantationPfeiffer, T., Lockowitz, C. R., Shenoy, S., Mavers, M., Hayashi, R., Bednarski, J. & Green, A., Aug 2024, In: Bone Marrow Transplantation. 59, 8, p. 1193-1195 3 p.Research output: Contribution to journal › Letter › peer-review
  • Approach for defining human adenovirus infection and disease for central review adjudication in clinical studies
    Approach for defining human adenovirus infection and disease for central review adjudication in clinical studiesFisher, B. T., Blumenstock, J., Boge, C. L. K., Shuster, S., Seif, A. E., Green, M., Michaels, M. G., Alexander, J. L., Ardura, M. I., Miller, T. P., Hijano, D. R., Muller, W. J., Schuster, J. E., Green, A. M., Dulek, D. E., Kajon, A. E. & Danziger-Isakov, L., May 2024, In: Pediatric transplantation. 28, 3, e14750.Research output: Contribution to journal › Article › peer-review
  • MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaks
    MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaksMathias, B., O'Leary, D., Saucier, N., Ahmad, F., White, L. S., Russell, L. M., Shinawi, M., Smith, M. J., Abraham, R. S., Cooper, M. A., Kitcharoensakkul, M., Green, A. M. & Bednarski, J. J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1113-1124.e7Research output: Contribution to journal › Article › peer-review
  • Virus-Specific T Cells for the Treatment of Systemic Infections Following Allogeneic Hematopoietic Cell and Solid Organ Transplantation
    Virus-Specific T Cells for the Treatment of Systemic Infections Following Allogeneic Hematopoietic Cell and Solid Organ TransplantationGreen, A., Rubinstein, J. D., Grimley, M. & Pfeiffer, T., Feb 1 2024, In: Journal of the Pediatric Infectious Diseases Society. 13, p. S49-S57Research output: Contribution to journal › Review article › peer-review
Complete research profile